Scientists at the University of Nottingham are attempting to create re-programmable cells inspired by computer operating systems. The research goes beyond the traditional scope of biological inquiry, understanding how living organisms work, to create new biological systems not found in nature.
The project combines the expertise of scientists in a number of different specialties. An important part of the research involves developing better computer models of cell behavior. To accomplish this task, biologists are joined by experts in computer science and informatics in the lab.
The researchers have already successfully programmed individual cells to complete tasks. The next step is to do the same with more complex organisms. Currently, the research is focused on e.coli bacteria.
The multi-disciplinary research is being conducted at the University of Nottingham, under the leadership of Professor Natalio Krasnogor, head of the Interdisciplinary Computing and Complex Systems Research Group.
Professor Krasnogor has been granted a leadership fellowship worth more than £1 million by the Engineering and Physical Sciences Research Council to fund the project. The scientific team in Nottingham is being assisted by a number of colleges from universities in the US, Scotland, Israel and Spain.
Professor Krasnogor describes the goal of the project as creating “a basic operating system for a biological cell.” He hopes that in the near future we will be able to compile, store and execute programs in cells.